WASHINGTON, DC (12/16/21) – The team behind STRmix â¢ – sophisticated forensic software used to resolve mixed DNA profiles previously considered too complex or degraded to interpret – is releasing significant enhancements for its DBLR â¢ investigation application.
Used in conjunction with STRmix â¢ to calculate millions of likelihood ratios (LRs) in seconds, the new version of DBLR â¢ (which stands for Database Likelihood Ratios) will feature:
- Improved modeling through introduction of bonds, mutations and FST in the Parentage module; and
- The ability to assign LRs in the Kinship module for single source profiles containing both STR and SNP loci generated using Next Generation Sequencing (NGS) technology.
Likelihood ratios are used to assess the strength of DNA evidence and the likelihood that DNA found at a crime scene belonged to specific individuals.
âImprovements to the Kinship module allow users to apply advanced models in a simple, streamlined solution,â says Dr. Maarten Kruijver, the developer of DBLR â¢. In addition, the new ability to assign LRs from NGS reference profiles is an important step forward, as the community continues to prepare for the emergence of NGS technology in forensic laboratories.
Other enhancements in the updated version of DBLR â¢ include the introduction of a direct match module for database-to-database comparisons and the inclusion of cluster charts in the mix-to-match match report. mixing, allowing a better visualization of the results.
Forensic labs using DBLR â¢ in conjunction with STRmix â¢ are able to visualize the value of DNA mix evidence, perform mix-to-mix comparisons and perform lightning-fast database searches . DBLR â¢ also offers increased accessibility since it can run on a user’s PC without the need for high performance computing.
âSince we implemented case processing with DBLR â¢, we have found DBLR â¢ to be very useful for multiple applications. We use DBLR â¢ to perform the identification of unidentified human remains, saving our analysts hours of manual kinship calculations, âsays Dr. Duncan Taylor, Chief Scientist – Forensic Statistics at Forensic Science SA ( and co-developer of STRmix â¢).
Dr Taylor adds, âWe are using DBLR â¢ to interrogate the discriminatory power of DNA profiles to help us make decisions about which analyzes to perform. We also found it to be extremely effective at generating cold case information when we looked at profiles spanning multiple elements and which may contain related or common DNA donors.
Dr Taylor developed STRmix â¢ with Dr John Buckleton, DSc, FRSNZ, and Dr Jo-Anne Bright, both of the New Zealand Institute of Environmental Science and Research (ESR).
STRmix â¢, DBLR â¢ and a third software package developed by the STRmix â¢ team, FaSTR â¢ DNA, complete the entire workflow, from analysis to interpretation and database mapping. FaSTR â¢ DNA quickly analyzes raw DNA data generated by genetic analyzers and standard profiling kits and assigns an estimate of the number of contributors (NoCs).
The effectiveness of these solutions, coupled with the successful experience established by STRmix â¢ in producing usable, interpretable and legally admissible DNA evidence in over 300,000 criminal cases, has led to their widespread adoption in medical laboratories. legal worldwide.
Currently, 69 federal, state and local agencies in the United States routinely use STRmix â¢ for DNA analysis. Internationally, nine state and territory forensic laboratories in Australia and New Zealand, and 14 laboratories in other countries, including the United Kingdom, Ireland, Canada, Finland, Switzerland and Denmark now use STRmix â¢.
For more information on STRmix products, visit www.strmix.com.